Cellosaurus cell line 965729-122-R-J2-PDC (CVCL

Cellosaurus 965729-122-R-J2-PDC (CVCL_F4DJ)

[Text][XML][JSON]

Cell line name

965729-122-R-J2-PDC

Accession

CVCL_F4DJ

Resource Identification Initiative

To cite this cell line use: 965729-122-R-J2-PDC (RRID:CVCL_F4DJ)

Comments

Part of: NCI Patient-Derived Model Repository.
Population: Caucasian; Utah residents with ancestry from Northern and Western Europe.
Characteristics: tumorigenic in NOD/SCID/IL2RgammaNULL (NSG) mice.
Characteristics: Established from a patient-derived xenograft (PDX) in NOD/SCID/IL2RgammaNULL (NSG) mice.
Doubling time: 28 hours (NCI-PDMR=8077).
Microsatellite instability: Stable (MSS) (NCI-PDMR=8077).
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Retroperitoneal lymph node; UBERON=UBERON_0035371.

Sequence variations

Mutation; HGNC; HGNC:950; BAP1; Simple; p.R385* (c.1153C>T); Zygosity=Homozygous; Note=Likely Oncogenic, variant allele frequency: 1 (NCI-PDMR=8077).
Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.X153_splice (c.458-2A>T); Zygosity=Homozygous; Note=Likely Oncogenic, variant allele frequency: 1 (NCI-PDMR=8077).
Mutation; HGNC; HGNC:7773; NF2; Simple; p.P275Nfs*22 (c.821_822dup); Zygosity=Homozygous; Note=Likely Oncogenic, variant allele frequency: 1 (NCI-PDMR=8077).
Mutation; HGNC; HGNC:17101; SUZ12; Simple; p.L564Sfs*5 (c.1688dup); Zygosity=Heterozygous; Note=Likely Oncogenic, variant allele frequency: 0.4761 (NCI-PDMR=8077).

HLA typing

Source: NCI-PDMR=8077

Class I
HLA-A	A*01:01,01:01
HLA-B	B*15:17,15:17
HLA-C	C*07:01,07:01

Disease

Papillary renal cell carcinoma (NCIt: C6975)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Male

Age at sampling

59Y