Cellosaurus cell line 693688-280-R-J1-PDC (CVCL

Cellosaurus 693688-280-R-J1-PDC (CVCL_F4DF)

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Cell line name

693688-280-R-J1-PDC

Accession

CVCL_F4DF

Resource Identification Initiative

To cite this cell line use: 693688-280-R-J1-PDC (RRID:CVCL_F4DF)

Comments

Part of: NCI Patient-Derived Model Repository.
Population: Caucasian; Utah residents with ancestry from Northern and Western Europe.
Characteristics: tumorigenic in NOD/SCID/IL2RgammaNULL (NSG) mice.
Doubling time: 23 hours (NCI-PDMR=3552).
Microsatellite instability: Stable (MSS) (NCI-PDMR=3552).
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Colon; UBERON=UBERON_0001155.

Sequence variations

Mutation; HGNC; HGNC:583; APC; Simple; p.R564* (c.1690C>T); Zygosity=Homozygous; Note=Likely Oncogenic, variant allele frequency: 1 (NCI-PDMR=3552).
Mutation; HGNC; HGNC:583; APC; Simple; p.L1488Yfs*19 (c.4463del); Zygosity=Homozygous; Note=Likely Oncogenic, variant allele frequency: 1 (NCI-PDMR=3552).
Mutation; HGNC; HGNC:18037; ARID2; Simple; p.S1351Vfs*3 (c.4051del); Zygosity=Heterozygous; Note=Likely Oncogenic, variant allele frequency: 0.455 (NCI-PDMR=3552).
Mutation; HGNC; HGNC:28434; FAM58A; Simple; p.C181* (c.542_543delinsAG); Zygosity=Heterozygous; Note=Likely Oncogenic, variant allele frequency: 0.4679 (NCI-PDMR=3552).
Mutation; HGNC; HGNC:11998; TP53; Simple; p.R273H (c.818G>A); Zygosity=Homozygous; Note=Oncogenic, variant allele frequency: 1 (NCI-PDMR=3552).

HLA typing

Source: NCI-PDMR=3552

Class I
HLA-A	A*02:01,02:01
HLA-B	B*35:03,51:01
HLA-C	C*04:01,04:01

Disease

Small Cell Neuroendocrine Carcinoma (NCIt: C3915)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Female

Age at sampling

62Y