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Cellosaurus 415267-285-R-J2-PDC (CVCL_F4DB)

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Cell line name 415267-285-R-J2-PDC
Accession CVCL_F4DB
Resource Identification Initiative To cite this cell line use: 415267-285-R-J2-PDC (RRID:CVCL_F4DB)
Comments Part of: NCI Patient-Derived Model Repository.
Population: African; Yoruba in Ibadan, Nigeria (YRI).
Characteristics: tumorigenic in NOD/SCID/IL2RgammaNULL (NSG) mice.
Characteristics: Established from a 3D organoid culture of a patient-derived xenograft (PDX) in NOD/SCID/IL2RgammaNULL (NSG) mice.
Doubling time: 43 hours (NCI-PDMR=8067).
Microsatellite instability: Stable (MSS) (NCI-PDMR=8067).
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Left breast; UBERON=UBERON_0000310.
Sequence variations
  • Mutation; HGNC; HGNC:13726; KMT2C; Simple; p.W3183_Q3194delins* (c.9548_9580del); Zygosity=Heterozygous; Note=Likely Oncogenic, variant allele frequency: 0.4156 (NCI-PDMR=8067).
  • Mutation; HGNC; HGNC:13726; KMT2C; Simple; p.S4677* (c.14030C>A); Zygosity=Heterozygous; Note=Likely Oncogenic, variant allele frequency: 0.5789 (NCI-PDMR=8067).
  • Mutation; HGNC; HGNC:7133; KMT2D; Simple; p.S2312* (c.6935C>G); Zygosity=Heterozygous; Note=Likely Oncogenic, variant allele frequency: 0.5251 (NCI-PDMR=8067).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.R273H (c.818G>A); Zygosity=Homozygous; Note=Oncogenic, variant allele frequency: 1 (NCI-PDMR=8067).
HLA typing Source: NCI-PDMR=8067
Class I
HLA-AA*02:02,33:03
HLA-BB*53:01,53:01
HLA-CC*03:02,04:01
Disease Breast Inflammatory Carcinoma (NCIt: C4001)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 73Y
Category Cancer cell line
STR profile Source(s): NCI-PDMR=8067

Markers:
AmelogeninX
CSF1PO10,12
D2S133820,21
D3S135813,15
D5S81811,13
D7S82010
D8S117914,15,16
D13S31711,12
D16S53911
D18S5115,17
D19S43313
D21S1129,30
FGA23
TH016,7
TPOX8,10
vWA14,17

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Cross-references
Cell line collections (Providers) NCI-PDMR; 8067
Entry history
Entry creation25-Jun-2026
Last entry update25-Jun-2026
Version number1