ID   415267-285-R-J2-PDC
AC   CVCL_F4DB
DR   NCI-PDMR; 8067
CC   Part of: NCI Patient-Derived Model Repository.
CC   Population: African; Yoruba in Ibadan, Nigeria (YRI).
CC   Characteristics: tumorigenic in NOD/SCID/IL2RgammaNULL (NSG) mice.
CC   Characteristics: Established from a 3D organoid culture of a patient-derived xenograft (PDX) in NOD/SCID/IL2RgammaNULL (NSG) mice.
CC   Doubling time: 43 hours (NCI-PDMR=8067).
CC   HLA typing: A*02:02,33:03; B*53:01,53:01; C*03:02,04:01 (NCI-PDMR=8067).
CC   Microsatellite instability: Stable (MSS) (NCI-PDMR=8067).
CC   Sequence variation: Mutation; HGNC; HGNC:13726; KMT2C; Simple; p.W3183_Q3194delins* (c.9548_9580del); Zygosity=Heterozygous; Note=Likely Oncogenic, variant allele frequency: 0.4156 (NCI-PDMR=8067).
CC   Sequence variation: Mutation; HGNC; HGNC:13726; KMT2C; Simple; p.S4677* (c.14030C>A); Zygosity=Heterozygous; Note=Likely Oncogenic, variant allele frequency: 0.5789 (NCI-PDMR=8067).
CC   Sequence variation: Mutation; HGNC; HGNC:7133; KMT2D; Simple; p.S2312* (c.6935C>G); Zygosity=Heterozygous; Note=Likely Oncogenic, variant allele frequency: 0.5251 (NCI-PDMR=8067).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.R273H (c.818G>A); Zygosity=Homozygous; Note=Oncogenic, variant allele frequency: 1 (NCI-PDMR=8067).
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Transcriptomics; RNAseq.
CC   Derived from site: In situ; Left breast; UBERON=UBERON_0000310.
ST   Source(s): NCI-PDMR=8067
ST   Amelogenin: X
ST   CSF1PO: 10,12
ST   D13S317: 11,12
ST   D16S539: 11
ST   D18S51: 15,17
ST   D19S433: 13
ST   D21S11: 29,30
ST   D2S1338: 20,21
ST   D3S1358: 13,15
ST   D5S818: 11,13
ST   D7S820: 10
ST   D8S1179: 14,15,16
ST   FGA: 23
ST   TH01: 6,7
ST   TPOX: 8,10
ST   vWA: 14,17
DI   NCIt; C4001; Breast Inflammatory Carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   73Y
CA   Cancer cell line
DT   Created: 25-06-26; Last updated: 25-06-26; Version: 1
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