Cellosaurus cell line 268233-264-R-J1-PDC (CVCL

Cellosaurus 268233-264-R-J1-PDC (CVCL_F4D8)

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Cell line name

268233-264-R-J1-PDC

Accession

CVCL_F4D8

Resource Identification Initiative

To cite this cell line use: 268233-264-R-J1-PDC (RRID:CVCL_F4D8)

Comments

Part of: NCI Patient-Derived Model Repository.
Population: African; Yoruba in Ibadan, Nigeria (YRI).
Characteristics: tumorigenic in NOD/SCID/IL2RgammaNULL (NSG) mice.
Characteristics: Established from a patient-derived xenograft (PDX) in NOD/SCID/IL2RgammaNULL (NSG) mice.
Doubling time: 35 hours (NCI-PDMR=12289).
Microsatellite instability: Stable (MSS) (NCI-PDMR=12289).
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Nose, nasal cavity, left maxillary sinus; UBERON=UBERON_0001764.

Sequence variations

Mutation; HGNC; HGNC:1748; CDH1; Simple; p.A617T (c.1849G>A); Zygosity=Heterozygous; Note=Likely Oncogenic, variant allele frequency: 0.3843 (NCI-PDMR=12289).
Mutation; HGNC; HGNC:6407; KRAS; Simple; p.G12D (c.35G>A); Zygosity=Heterozygous; Note=Oncogenic, variant allele frequency: 0.5465 (NCI-PDMR=12289).
Mutation; HGNC; HGNC:7326; MSH3; Simple; p.A60Pfs*23 (c.177_178insCCCCCAGC); Zygosity=Homozygous; Note=Likely Oncogenic, variant allele frequency: 1 (NCI-PDMR=12289).
Mutation; HGNC; HGNC:7326; MSH3; Simple; p.A61Pfs*25 (c.180_181insCCCA); Zygosity=Homozygous; Note=Likely Oncogenic, variant allele frequency: 1 (NCI-PDMR=12289).
Mutation; HGNC; HGNC:11998; TP53; Simple; p.S183* (c.548C>G); Zygosity=Homozygous; Note=Likely Oncogenic, variant allele frequency: 1 (NCI-PDMR=12289).

HLA typing

Source: NCI-PDMR=12289

Class I
HLA-A	A*30:02,68:01
HLA-B	B*08:01,44:03
HLA-C	C*03:04,04:01

Disease

Sinus Squamous Cell Carcinoma (NCIt: C68611)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Female

Age at sampling

58Y