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Cellosaurus MDA-MB-231 NEDD8 KO (CVCL_F4BT)

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Cell line name MDA-MB-231 NEDD8 KO
Synonyms MDA-MB-231, NEDD8 KO
Accession CVCL_F4BT
Resource Identification Initiative To cite this cell line use: MDA-MB-231 NEDD8 KO (RRID:CVCL_F4BT)
Comments Group: Triple negative breast cancer (TNBC) cell line.
Population: Caucasian.
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:7732; NEDD8.
Omics: Phenotyping; CRISPR screening.
Omics: Proteomics; Quantitative.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Gly464Val (c.1391G>T); ClinVar=VCV000040364; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg280Lys (c.839G>A); ClinVar=VCV000376657; Zygosity=Homozygous (from parent cell line).
Disease Breast adenocarcinoma (NCIt: C5214)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0062 (MDA-MB-231)
Sex of cell Female
Age at sampling 51Y
Category Cancer cell line
Publications

PubMed=38678024; DOI=10.1038/s41467-024-47987-x; PMCID=PMC11055868
Irineos Papakyriacou, Ginte Kutkaite, Marta Rubies Bedos, Divya Nagarajan, Liam P. Alford, Michael P. Menden, Yumeng Mao;
Loss of NEDD8 in cancer cells causes vulnerability to immune checkpoint blockade in triple-negative breast cancer.
Nat. Commun. 15:3581-3581(2024)

Cross-references
Proteomic databases PRIDE; PXD051061
Entry history
Entry creation31-Mar-2026
Last entry update31-Mar-2026
Version number1