ID   MDA-MB-231 NEDD8 KO
AC   CVCL_F4BT
SY   MDA-MB-231, NEDD8 KO
DR   PRIDE; PXD051061
RX   PubMed=38678024;
CC   Group: Triple negative breast cancer (TNBC) cell line.
CC   Population: Caucasian.
CC   Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:7732; NEDD8.
CC   Sequence variation: Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Gly464Val (c.1391G>T); ClinVar=VCV000040364; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg280Lys (c.839G>A); ClinVar=VCV000376657; Zygosity=Homozygous (from parent cell line).
CC   Omics: Phenotyping; CRISPR screening.
CC   Omics: Proteomics; Quantitative.
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C5214; Breast adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0062 ! MDA-MB-231
SX   Female
AG   51Y
CA   Cancer cell line
DT   Created: 31-03-26; Last updated: 31-03-26; Version: 1
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RX   PubMed=38678024; DOI=10.1038/s41467-024-47987-x; PMCID=PMC11055868;
RA   Papakyriacou, Irineos
RA   Kutkaite, Ginte
RA   Rubies Bedos, Marta
RA   Nagarajan, Divya
RA   Alford, Liam P.
RA   Menden, Michael P.
RA   Mao, Yumeng
RT   "Loss of NEDD8 in cancer cells causes vulnerability to immune
RT   checkpoint blockade in triple-negative breast cancer.";
RL   Nat. Commun. 15:3581-3581(2024).
//