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Cellosaurus BP [Mouse melanoma] (CVCL_F2AQ)

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Cell line name BP [Mouse melanoma]
Accession CVCL_F2AQ
Resource Identification Initiative To cite this cell line use: BP [Mouse melanoma] (RRID:CVCL_F2AQ)
Comments Genetic integration: Method=Transgenic mouse; Gene=MGI; MGI:1352467; Esr1 (Note=Ligand binding domain; with p.Gly525Arg. Fused to Cre = CreERT2).
Genetic integration: Method=Transgenic mouse; Gene=UniProtKB; P06956; Escherichia phage P1 cre (Note=Fused to ligand domain of mouse Esr1 = CreERT2).
Breed/subspecies: C57BL/6 Braf+/LSL-BrafV600E;Ptenlox/lox;Tyr::CreERT2+/o transgenic.
Sequence variations
  • Gene deletion; MGI; MGI:97787; Pten; Zygosity=Homozygous (PubMed=24903021).
  • Mutation; MGI; MGI:88190; Braf; Simple; p.Val637Glu (c.1910T>A); Zygosity=Heterozygous (PubMed=24903021).
Disease Mouse melanoma (NCIt: C21790)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): Direct_author_submission

Markers:
Mouse STR 1-110
Mouse STR 1-219
Mouse STR 2-19,16
Mouse STR 3-214
Mouse STR 4-219.3,20.3
Mouse STR 5-513,17
Mouse STR 6-417,18
Mouse STR 6-717
Mouse STR 7-127.2
Mouse STR 8-115,16
Mouse STR 11-215,16
Mouse STR 12-117
Mouse STR 13-117
Mouse STR 15-323.3
Mouse STR 17-215,16
Mouse STR 18-316
Mouse STR 19-213
Mouse STR X-127

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Publications

PubMed=24903021; DOI=10.1158/2326-6066.CIR-13-0215; PMCID=PMC4097121
Zachary A. Cooper, Vikram R. Juneja, Peter T. Sage, Dennie T. Frederick, Adriano Piris, Devarati Mitra, Jennifer A. Lo, F.Stephen Hodi, Gordon J. Freeman, Marcus W. Bosenberg, Martin McMahon ...Show all 15 authors... , Keith T. Flaherty, David E. Fisher, Arlene H. Sharpe, Jennifer A. Wargo; Show fewer authors
Response to BRAF inhibition in melanoma is enhanced when combined with immune checkpoint blockade.
Cancer Immunol. Res. 2:643-654(2014)

Entry history
Entry creation31-Mar-2026
Last entry update31-Mar-2026
Version number1