ID   BP [Mouse melanoma]
AC   CVCL_F2AQ
RX   PubMed=24903021;
CC   Sequence variation: Gene deletion; MGI; MGI:97787; Pten; Zygosity=Homozygous (PubMed=24903021).
CC   Sequence variation: Mutation; MGI; MGI:88190; Braf; Simple; p.Val637Glu (c.1910T>A); Zygosity=Heterozygous (PubMed=24903021).
CC   Genetic integration: Method=Transgenic mouse; Gene=MGI; MGI:1352467; Esr1 (Note=Ligand binding domain; with p.Gly525Arg. Fused to Cre = CreERT2).
CC   Genetic integration: Method=Transgenic mouse; Gene=UniProtKB; P06956; Escherichia phage P1 cre (Note=Fused to ligand domain of mouse Esr1 = CreERT2).
CC   Breed/subspecies: C57BL/6 Braf+/LSL-BrafV600E;Ptenlox/lox;Tyr::CreERT2+/o transgenic.
ST   Source(s): Direct_author_submission
ST   Mouse STR 1-1: 10
ST   Mouse STR 1-2: 19
ST   Mouse STR 2-1: 9,16
ST   Mouse STR 3-2: 14
ST   Mouse STR 4-2: 19.3,20.3
ST   Mouse STR 5-5: 13,17
ST   Mouse STR 6-4: 17,18
ST   Mouse STR 6-7: 17
ST   Mouse STR 7-1: 27.2
ST   Mouse STR 8-1: 15,16
ST   Mouse STR 11-2: 15,16
ST   Mouse STR 12-1: 17
ST   Mouse STR 13-1: 17
ST   Mouse STR 15-3: 23.3
ST   Mouse STR 17-2: 15,16
ST   Mouse STR 18-3: 16
ST   Mouse STR 19-2: 13
ST   Mouse STR X-1: 27
DI   NCIt; C21790; Mouse melanoma
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
SX   Sex unspecified
AG   Age unspecified
CA   Cancer cell line
DT   Created: 31-03-26; Last updated: 31-03-26; Version: 1
//
RX   PubMed=24903021; DOI=10.1158/2326-6066.CIR-13-0215; PMCID=PMC4097121;
RA   Cooper, Zachary A.
RA   Juneja, Vikram R.
RA   Sage, Peter T.
RA   Frederick, Dennie T.
RA   Piris, Adriano
RA   Mitra, Devarati
RA   Lo, Jennifer A.
RA   Hodi, F.Stephen
RA   Freeman, Gordon J.
RA   Bosenberg, Marcus W.
RA   McMahon, Martin
RA   Flaherty, Keith T.
RA   Fisher, David E.
RA   Sharpe, Arlene H.
RA   Wargo, Jennifer A.
RT   "Response to BRAF inhibition in melanoma is enhanced when combined
RT   with immune checkpoint blockade.";
RL   Cancer Immunol. Res. 2:643-654(2014).
//