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Cellosaurus MCF-7 R3 (CVCL_F1Z2)

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Cell line name MCF-7 R3
Synonyms R3
Accession CVCL_F1Z2
Resource Identification Initiative To cite this cell line use: MCF-7 R3 (RRID:CVCL_F1Z2)
Comments Population: Caucasian.
Characteristics: Estrogen-independant (PubMed=7240250).
Doubling time: 2.4 days (PubMed=7240250).
Selected for resistance to: ChEBI; CHEBI_41774; Tamoxifen.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Publications

PubMed=7240250; DOI=10.1016/S0021-9258(19)69076-9
Hajime Nawata, Ming-Ta Chong, Diane A. Bronzert, Marc E. Lippman;
Estradiol-independent growth of a subline of MCF-7 human breast cancer cells in culture.
J. Biol. Chem. 256:6895-6902(1981)

Entry history
Entry creation27-Nov-2025
Last entry update27-Nov-2025
Version number1