ID   MCF-7 R3
AC   CVCL_F1Z2
SY   R3
RX   PubMed=7240250;
CC   Population: Caucasian.
CC   Characteristics: Estrogen-independant (PubMed=7240250).
CC   Doubling time: 2.4 days (PubMed=7240250).
CC   Selected for resistance to: ChEBI; CHEBI_41774; Tamoxifen.
CC   Sequence variation: Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C4194; Invasive breast carcinoma of no special type
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0031 ! MCF-7
SX   Female
AG   69Y
CA   Cancer cell line
DT   Created: 27-11-25; Last updated: 27-11-25; Version: 1
//
RX   PubMed=7240250; DOI=10.1016/S0021-9258(19)69076-9;
RA   Nawata, Hajime
RA   Chong, Ming-Ta
RA   Bronzert, Diane A.
RA   Lippman, Marc E.
RT   "Estradiol-independent growth of a subline of MCF-7 human breast
RT   cancer cells in culture.";
RL   J. Biol. Chem. 256:6895-6902(1981).
//