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Cellosaurus 2F8 [Mouse hybridoma against human EGFR] (CVCL_F1XQ)

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Cell line name 2F8 [Mouse hybridoma against human EGFR]
Accession CVCL_F1XQ
Resource Identification Initiative To cite this cell line use: 2F8 [Mouse hybridoma against human EGFR] (RRID:CVCL_F1XQ)
Comments Biotechnology: The monoclonal antibody produced by this hybridoma is known as zalutumumab and was intended to be used for the treatment of head and neck cancers but was abandonned due to lack of benefits.
Monoclonal antibody isotype: IgG1, kappa.
Monoclonal antibody target: UniProtKB; P00533; Human EGFR (Note=Immunized with both A-431 cells (Cellosaurus=CVCL_0037) and purified EGFR).
Miscellaneous: As the immunized splenic B-cells are from HuMAb mice the produced mAB is of human origin.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Hierarchy Parent: CVCL_4032 (P3X63Ag8.653)
Category Hybridoma
Publications

PubMed=15383606; DOI=10.4049/jimmunol.173.7.4699
Wim K. Bleeker, Jeroen J. Lammerts van Bueren, Heidi H. van Ojik, Arnout F. Gerritsen, Marielle Pluyter, Mischa Antonius Houtkamp, Edward L. Halk, Joel Goldstein, Janine Schuurman, Marcus Antonius van Dijk, Jan G.J. van de Winkel, Paul W.H.I. Parren;
Dual mode of action of a human anti-epidermal growth factor receptor monoclonal antibody for cancer therapy.
J. Immunol. 173:4699-4707(2004)

Patent=US7247301
Jan G.J. van de Winkel, Marcus Antonius van Dijk, Arnout F. Gerritsen, Edward L. Halk;
Human monoclonal antibodies to epidermal growth factor receptor (EGFR).
Patent number US7247301, 24-Jul-2007

Cross-references
Biological sample resources ABCD; ABCD_AH809
Entry history
Entry creation27-Nov-2025
Last entry update27-Nov-2025
Version number1