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Cellosaurus HEK293T METTL18 KO METTL18-HA (CVCL_F1XG)

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Cell line name HEK293T METTL18 KO METTL18-HA
Synonyms METTL18 KO HEK293T with stable METTL18 expression
Accession CVCL_F1XG
Resource Identification Initiative To cite this cell line use: HEK293T METTL18 KO METTL18-HA (RRID:CVCL_F1XG)
Comments Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:28793; METTL18.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:28793; METTL18 (Note=With a C-terminal HA tag).
Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR).
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Genetic integration: Method=Transfection; Gene=UniProtKB; P03070; Simian virus 40 (SV40) large T antigen.
Transformant: NCBI_TaxID; 28285; Human adenovirus C serotype 5.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) (Note=tsA).
Derived from site: In situ; Fetal kidney; UBERON=UBERON_0002113.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_F1XD (HEK293T METTL18 KO)
Sex of cell Female
Age at sampling Fetus
Category Transformed cell line
Publications

PubMed=35674491; DOI=10.7554/eLife.72780; PMCID=PMC9177149
Eriko Matsuura-Suzuki, Tadahiro Shimazu, Mari Takahashi, Kaoru Kotoshiba, Takehiro Suzuki, Kazuhiro Kashiwagi, Yoshihiro Sohtome, Mai Akakabe, Mikiko Sodeoka, Naoshi Dohmae, Takuhiro Ito ...Show all 13 authors... , Yoichi Shinkai, Shintaro Iwasaki; Show fewer authors
METTL18-mediated histidine methylation of RPL3 modulates translation elongation for proteostasis maintenance.
eLife 11:e72780.1-e72780.33(2022)

Entry history
Entry creation27-Nov-2025
Last entry update27-Nov-2025
Version number1