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Cellosaurus HyCyte U-937 KO-hIL1RAP (CVCL_F1UX)

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Cell line name HyCyte U-937 KO-hIL1RAP
Synonyms hIL1RAP knockout U-937
Accession CVCL_F1UX
Resource Identification Initiative To cite this cell line use: HyCyte U-937 KO-hIL1RAP (RRID:CVCL_F1UX)
Comments Population: Caucasian.
Doubling time: 95-100 hours (Hysigen=CGKO-M2741).
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:5995; IL1RAP.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; HGNC:16063; MLLT10 + HGNC; HGNC:15514; PICALM; Name(s)=PICALM-MLLT10, CALM-AF10 (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Gly129fs*51 (c.387_388insCGCC); Zygosity=Hemizygous (from parent cell line).
  • Mutation; HGNC; HGNC:9644; PTPN11; Simple; p.Gly60Arg (c.178G>C); ClinVar=VCV000372590; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; c.559+1G>A (p.Val173Trpfs*59); ClinVar=VCV000428908; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
  • Mutation; HGNC; HGNC:12796; WT1; Simple; p.Arg301Ter (c.901C>T) (p.Arg352Ter, c.1054C>T) (p.Arg374Ter, c.1120C>T); ClinVar=VCV000449416; Zygosity=Heterozygous (from parent cell line).
Disease Adult acute monocytic leukemia (NCIt: C8263)
Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0007 (U-937)
Sex of cell Male
Age at sampling 37Y
Category Cancer cell line
Cross-references
Cell line collections (Providers) Hysigen; CGKO-M2741
Entry history
Entry creation27-Nov-2025
Last entry update27-Nov-2025
Version number1