Cellosaurus cell line HyCyte NCI-H460 KO-hIMPDH2 (CVCL

Cross-references
Cell line name	HyCyte NCI-H460 KO-hIMPDH2
Synonyms	hIMPDH2 knockout NCI-H460
Accession	CVCL_F1SB
Resource Identification Initiative	To cite this cell line use: HyCyte NCI-H460 KO-hIMPDH2 (RRID:CVCL_F1SB)
Comments	Population: Caucasian. Doubling time: 36-48 hours (Hysigen=CGKO-M2763). Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:6053; IMPDH2. Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations	Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gln61His (c.183A>T); ClinVar=VCV000045117; Zygosity=Homozygous (from parent cell line). Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (from parent cell line).
Disease	Lung large cell carcinoma (NCIt: C4450)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_0459 (NCI-H460)
Sex of cell	Male
Age at sampling	Age unspecified
Category	Cancer cell line
Cell line collections (Providers)	Hysigen; CGKO-M2763
Entry history
Entry creation	27-Nov-2025
Last entry update	27-Nov-2025
Version number	1