ID   HyCyte NCI-H460 KO-hIMPDH2
AC   CVCL_F1SB
SY   hIMPDH2 knockout NCI-H460
DR   Hysigen; CGKO-M2763
CC   Population: Caucasian.
CC   Doubling time: 36-48 hours (Hysigen=CGKO-M2763).
CC   Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:6053; IMPDH2.
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gln61His (c.183A>T); ClinVar=VCV000045117; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C4450; Lung large cell carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0459 ! NCI-H460
SX   Male
AG   Age unspecified
CA   Cancer cell line
DT   Created: 27-11-25; Last updated: 27-11-25; Version: 1
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