Cellosaurus cell line HyCyte A-375 KO-hSYVN1 (CVCL

Cross-references
Cell line name	HyCyte A-375 KO-hSYVN1
Synonyms	hSYVN1 knockout A-375
Accession	CVCL_F1LQ
Resource Identification Initiative	To cite this cell line use: HyCyte A-375 KO-hSYVN1 (RRID:CVCL_F1LQ)
Comments	Population: Caucasian. Doubling time: 18-24 hours (Hysigen=CGKO-M3235). Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:20738; SYVN1. Derived from site: In situ; Leg, skin; UBERON=UBERON_0001511.
Sequence variations	Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (from parent cell line). Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Glu61Ter (c.181G>T) (p.Gly75Val, c.224G>T); ClinVar=VCV000376309; Zygosity=Homozygous (from parent cell line). Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Glu69Ter (c.205G>T) (p.Gly83Val, c.248G>T); ClinVar=VCV000376308; Zygosity=Homozygous (from parent cell line). Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease	Amelanotic melanoma (NCIt: C3802)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_0132 (A-375)
Sex of cell	Female
Age at sampling	54Y
Category	Cancer cell line
Cell line collections (Providers)	Hysigen; CGKO-M3235
Entry history
Entry creation	27-Nov-2025
Last entry update	27-Nov-2025
Version number	1