Cellosaurus cell line HyCyte 786-O KO-hBAP1 (CVCL

Cross-references
Cell line name	HyCyte 786-O KO-hBAP1
Synonyms	hBAP1 knockout 786-O
Accession	CVCL_F1LP
Resource Identification Initiative	To cite this cell line use: HyCyte 786-O KO-hBAP1 (RRID:CVCL_F1LP)
Comments	Population: Caucasian. Doubling time: 48-60 hours (Hysigen=CGKO-M3198). Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:950; BAP1. Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
Sequence variations	Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Gln149Ter (c.445C>T); ClinVar=VCV000404164; Zygosity=Homozygous (from parent cell line). Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line). Mutation; HGNC; HGNC:11998; TP53; Simple; c.560-2A>G; ClinVar=VCV003148158; Zygosity=Heterozygous; Note=Splice acceptor mutation (from parent cell line). Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro278Ala (c.832C>G); ClinVar=VCV000376645; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:12687; VHL; Simple; p.Gly104Alafs*55 (c.311delG); Zygosity=Homozygous (from parent cell line).
Disease	Renal cell carcinoma (NCIt: C9385) Renal cell carcinoma (ORDO: Orphanet_217071)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_1051 (786-O)
Sex of cell	Male
Age at sampling	58Y
Category	Cancer cell line
Cell line collections (Providers)	Hysigen; CGKO-M3198
Entry history
Entry creation	27-Nov-2025
Last entry update	27-Nov-2025
Version number	1