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Cellosaurus MDA-MB-435E (CVCL_F0XN)

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Cell line name MDA-MB-435E
Accession CVCL_F0XN
Resource Identification Initiative To cite this cell line use: MDA-MB-435E (RRID:CVCL_F0XN)
Comments Problematic cell line: Contaminated. Parent cell line (MDA-MB-435) has been shown to be a M14 derivative.
Population: Caucasian.
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:1748; CDH1.
Genetic integration: Method=Transfection; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR).
Derived from site: Metastatic; Right buttock, hypodermis; UBERON=UBERON_0013691+UBERON_0002072.
Sequence variations
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; c.150+2T>C (IVS1+2T>C); ClinVar=VCV000406712; Zygosity=Heterozygous; Note=Splice donor mutation (from parent cell line).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; c.455insCdel26; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gly266Glu (c.797G>A); ClinVar=VCV000161516; Zygosity=Heterozygous (from parent cell line).
Disease Amelanotic melanoma (NCIt: C3802)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0417 (MDA-MB-435)
Sex of cell Male
Age at sampling 33Y
Category Cancer cell line
Publications

PubMed=10545506; DOI=10.1083/jcb.147.3.631; PMCID=PMC2151177
Marvin T. Nieman, Ryan Sanford Prudoff, Keith R. Johnson, Margaret Jean Wheelock;
N-cadherin promotes motility in human breast cancer cells regardless of their E-cadherin expression.
J. Cell Biol. 147:631-644(1999)

Entry history
Entry creation27-Nov-2025
Last entry update27-Nov-2025
Version number1