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Cellosaurus K-562 GATA2 clone G2-4 (CVCL_F0X5)

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Cell line name K-562 GATA2 clone G2-4
Synonyms G2-4
Accession CVCL_F0X5
Resource Identification Initiative To cite this cell line use: K-562 GATA2 clone G2-4 (RRID:CVCL_F0X5)
Comments Population: Caucasian.
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:4171; GATA2.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln136fs*13 (c.406_407insC); Zygosity=Homozygous (from parent cell line).
Disease Blast phase chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C9110)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0004 (K-562)
Sex of cell Female
Age at sampling 53Y
Category Cancer cell line
Publications

PubMed=11146164; DOI=10.1016/s0301-472x(00)00553-1
Pranvera Ikonomi, Candido E. Rivera, Michael Riordan, Glennelle Clark Washington, Alan Neil Schechter, Constance Tom Noguchi;
Overexpression of GATA-2 inhibits erythroid and promotes megakaryocyte differentiation.
Exp. Hematol. 28:1423-1431(2000)

Entry history
Entry creation27-Nov-2025
Last entry update27-Nov-2025
Version number1