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Cellosaurus U2OS-TMEM192-3xHA (CVCL_F0QI)

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Cell line name U2OS-TMEM192-3xHA
Synonyms U2OS:TMEM192-3xHA
Accession CVCL_F0QI
Resource Identification Initiative To cite this cell line use: U2OS-TMEM192-3xHA (RRID:CVCL_F0QI)
Comments Population: Caucasian.
Characteristics: Transfected with a pLJC5-Tmem192-3xHA construct (DOI=10.1101/2023.09.11.557213).
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:26775; TMEM192 (Note=With a 3xHA tag).
Genetic integration: Method=Transfection; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR).
Derived from site: In situ; Bone, tibia; UBERON=UBERON_0000979.
Sequence variations
  • Mutation; HGNC; HGNC:9277; PPM1D; Simple; p.Arg458Ter (c.1372C>T); ClinVar=VCV002445214; Zygosity=Heterozygous (from parent cell line).
Disease Osteosarcoma (NCIt: C9145)
Osteosarcoma (ORDO: Orphanet_668)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0042 (U2OS)
Sex of cell Female
Age at sampling 15Y
Category Cancer cell line
Publications

DOI=10.1101/2023.09.11.557213
Mai Nguyen, Jack J. Collier, Olesia Ignatenko, Genevieve Morin, Si-Dong Huang, Michel Desjardins, Heidi M. McBride;
Parkinson's genes orchestrate pyroptosis through selective trafficking of mtDNA to leaky lysosomes.
bioRxiv 2023:09.11.557213-09.11.557213(2023)

Entry history
Entry creation27-Nov-2025
Last entry update27-Nov-2025
Version number1