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Cellosaurus LNCaP C4-2B TaxR (CVCL_F0LA)

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Cell line name LNCaP C4-2B TaxR
Synonyms TaxR
Accession CVCL_F0LA
Resource Identification Initiative To cite this cell line use: LNCaP C4-2B TaxR (RRID:CVCL_F0LA)
Comments Population: Caucasian.
Characteristics: Overexpresses ABCB1 (PubMed=23861346).
Selected for resistance to: ChEBI; CHEBI_4672; Docetaxel anhydrous (Taxotere).
Omics: Transcriptomics; Microarray.
Derived from site: Metastatic; Left supraclavicular lymph node; UBERON=UBERON_8480056.
Sequence variations
  • Mutation; HGNC; HGNC:644; AR; Simple; p.Thr878Ala (c.2632A>G); ClinVar=VCV000009831; Zygosity=Hemizygous (from parent cell line).
  • Mutation; HGNC; HGNC:7010; MEN1; Simple; p.Tyr318Ter (c.954T>G) (p.Tyr313Ter, c.939T>A); ClinVar=VCV000439894; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8979; PIK3R1; Simple; p.Arg639Ter (c.1915C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys6Argfs*4 (c.17_18delAA); ClinVar=VCV000231649; Zygosity=Unspecified (from parent cell line).
Disease Prostate carcinoma (NCIt: C4863)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_4784 (LNCaP C4-2B)
Sex of cell Male
Age at sampling 50Y
Category Cancer cell line
Publications

PubMed=23861346; DOI=10.1158/1535-7163.MCT-13-0208; PMCID=PMC3947549
Ye-Zi Zhu, Cheng-Fei Liu, Nagalakshmi Nadiminty, Wei Lou, Ramakumar Tummala, Christopher P. Evans, Allen C. Gao;
Inhibition of ABCB1 expression overcomes acquired docetaxel resistance in prostate cancer.
Mol. Cancer Ther. 12:1829-1836(2013)

Entry history
Entry creation14-Aug-2025
Last entry update14-Aug-2025
Version number1