ID   LNCaP C4-2B TaxR
AC   CVCL_F0LA
SY   TaxR
RX   PubMed=23861346;
CC   Population: Caucasian.
CC   Characteristics: Overexpresses ABCB1 (PubMed=23861346).
CC   Selected for resistance to: ChEBI; CHEBI_4672; Docetaxel anhydrous (Taxotere).
CC   Sequence variation: Mutation; HGNC; HGNC:644; AR; Simple; p.Thr878Ala (c.2632A>G); ClinVar=VCV000009831; Zygosity=Hemizygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:7010; MEN1; Simple; p.Tyr318Ter (c.954T>G) (p.Tyr313Ter, c.939T>A); ClinVar=VCV000439894; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:8979; PIK3R1; Simple; p.Arg639Ter (c.1915C>T); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys6Argfs*4 (c.17_18delAA); ClinVar=VCV000231649; Zygosity=Unspecified (from parent cell line).
CC   Omics: Transcriptomics; Microarray.
CC   Derived from site: Metastatic; Left supraclavicular lymph node; UBERON=UBERON_8480056.
DI   NCIt; C4863; Prostate carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_4784 ! LNCaP C4-2B
SX   Male
AG   50Y
CA   Cancer cell line
DT   Created: 14-08-25; Last updated: 14-08-25; Version: 1
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RX   PubMed=23861346; DOI=10.1158/1535-7163.MCT-13-0208; PMCID=PMC3947549;
RA   Zhu, Ye-Zi
RA   Liu, Cheng-Fei
RA   Nadiminty, Nagalakshmi
RA   Lou, Wei
RA   Tummala, Ramakumar
RA   Evans, Christopher P.
RA   Gao, Allen C.
RT   "Inhibition of ABCB1 expression overcomes acquired docetaxel
RT   resistance in prostate cancer.";
RL   Mol. Cancer Ther. 12:1829-1836(2013).
//