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Cellosaurus ELT3 TSC2 (CVCL_F0KL)

[Text version]
Cell line name ELT3 TSC2
Synonyms TSC2 ELT-3
Accession CVCL_F0KL
Resource Identification Initiative To cite this cell line use: ELT3 TSC2 (RRID:CVCL_F0KL)
Comments Genetic integration: Method=Transduction; Gene=HGNC; HGNC:12363; TSC2.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Sequence variations
  • Mutation; RGD; 3908; Tsc2; Simple; p.Val1272fs; Zygosity=Heterozygous; Note=Insertion of a 5 kb retrotransposon (from inference of genetic background of other Eker-derived cell lines).
Disease Rat leiomyoma (NCIt: C60426)
Species of origin Rattus norvegicus (Rat) (NCBI Taxonomy: 10116)
Breed/subspecies: Eker x Long-Evans; RS=RS_0000385+RS_0000347.
Hierarchy Parent: CVCL_4616 (ELT3)
Sex of cell Female
Age at sampling 11-19M
Category Cancer cell line
Publications

PubMed=15039427; DOI=10.1074/jbc.M401912200
Geraldine A. Finlay, Brian York, Richard H. Karas, Barry Lee Fanburg, Hong-Bing Zhang, David Joseph Kwiatkowski, Daniel J. Noonan;
Estrogen-induced smooth muscle cell growth is regulated by tuberin and associated with altered activation of platelet-derived growth factor receptor-beta and ERK-1/2.
J. Biol. Chem. 279:23114-23122(2004)

Entry history
Entry creation14-Aug-2025
Last entry update14-Aug-2025
Version number1