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Cellosaurus A431-PR (CVCL_EQ67)

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Cell line name A431-PR
Synonyms A431 PR
Accession CVCL_EQ67
Resource Identification Initiative To cite this cell line use: A431-PR (RRID:CVCL_EQ67)
Comments Population: Caucasian.
Knockout cell: Method=shRNA knockdown; HGNC; HGNC:9588; PTEN.
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Skin, epidermis; UBERON=UBERON_0001003.
Sequence variations
  • Gene fusion; HGNC; HGNC:3236; EGFR + HGNC; HGNC:9237; PPARGC1A; Name(s)=EGFR-PPARGC1A (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Unspecified (from parent cell line).
Disease Skin squamous cell carcinoma (NCIt: C4819)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0037 (A-431)
Sex of cell Female
Age at sampling 85Y
Category Cancer cell line
Publications

PubMed=17560336; DOI=10.1016/j.ccr.2007.04.021
Igor Vivanco, Nicolaos Palaskas, Chris Tran, Stephen P. Finn, Gad Getz, Norman J. Kennedy, Jing Jiao, Joshua Rose, Wan-Ling Xie, Massimo Loda, Todd Robert Golub ...Show all 15 authors... , Ingo K. Mellinghoff, Roger John Davis, Hong Wu, Charles Lazelle Sawyers; Show fewer authors
Identification of the JNK signaling pathway as a functional target of the tumor suppressor PTEN.
Cancer Cell 11:555-569(2007)

Cross-references
Cell line databases/resources cancercelllines; CVCL_EQ67
Encyclopedic resources Wikidata; Q54606915
Gene expression databases GEO; GSM183434
GEO; GSM183435
Entry history
Entry creation26-Sep-2016
Last entry update10-Apr-2025
Version number14