| Cell line name |
U937(V) |
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| Synonyms |
U937V; U-937V; U937(M); U937M |
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| Accession |
CVCL_E9WX |
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| Resource Identification Initiative |
To cite this cell line use: U937(V) (RRID:CVCL_E9WX) |
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| Comments |
Population: Caucasian.
Characteristics: Sensitive to cytotoxic action of TNF in the presence and in the absence of cycloheximide (CHX) (PubMed=11292320).
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175. |
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| Sequence variations |
- Gene fusion; HGNC; HGNC:16063; MLLT10 + HGNC; HGNC:15514; PICALM; Name(s)=PICALM-MLLT10, CALM-AF10 (from parent cell line).
- Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Gly129fs*51 (c.387_388insCGCC); Zygosity=Hemizygous (from parent cell line).
- Mutation; HGNC; HGNC:9644; PTPN11; Simple; p.Gly60Arg (c.178G>C); ClinVar=VCV000372590; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; c.559+1G>A (p.Val173Trpfs*59); ClinVar=VCV000428908; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
- Mutation; HGNC; HGNC:12796; WT1; Simple; p.Arg301Ter (c.901C>T) (p.Arg352Ter, c.1054C>T) (p.Arg374Ter, c.1120C>T); ClinVar=VCV000449416; Zygosity=Heterozygous (from parent cell line).
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| Disease |
Adult acute monocytic leukemia (NCIt: C8263)
Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0007 (U-937) |
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| Sex of cell |
Male |
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| Age at sampling |
37Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=11292320; DOI=10.1006/cyto.2001.0844
Lucyna Kaszubowska, Hartmut Engelmann, Magdalena Gotartowska, Mariola Iliszko, Jacek Jerzy Bigda;
Identification of two U937 cell sublines exhibiting different patterns of response to tumour necrosis factor.
Cytokine 13:365-370(2001) PubMed=23605997; DOI=10.2478/s11658-013-0087-y; PMCID=PMC6275624
Grzegorz Stasilojc, Sandra Pinto, Roksana Wyszkowska, Magda Wejda, Ewa Maria Slominska, Martyna Filipska, Patrycja Koszalka, Julian Swierczynski, Jose Enrique O'Connor, Jacek Jerzy Bigda;
U937 variant cells as a model of apoptosis without cell disintegration.
Cell. Mol. Biol. Lett. 18:249-262(2013) PubMed=36982453; DOI=10.3390/ijms24065377; PMCID=PMC10049680
Rafal Skopek, Malgorzata Palusinska, Katarzyna Kaczor-Keller, Rafal Pingwara, Anna Papierniak-Wygladala, Tino Schenk, Slawomir Lewicki, Artur Zelent, Lukasz Szymanski;
Choosing the right cell line for acute myeloid leukemia (AML) research.
Int. J. Mol. Sci. 24:5377.1-5377.34(2023) |
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| Entry history |
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| Entry creation | 14-Aug-2025 |
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| Last entry update | 14-Aug-2025 |
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| Version number | 1 |
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