| Cell line name |
MDA-MB-231 HSP90AA1 KO#2 |
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| Synonyms |
KO-alpha-#2; KO-alpha#2 |
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| Accession |
CVCL_E9EB |
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| Resource Identification Initiative |
To cite this cell line use: MDA-MB-231 HSP90AA1 KO#2 (RRID:CVCL_E9EB) |
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| Comments |
Group: Triple negative breast cancer (TNBC) cell line.
Population: Caucasian.
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:5253; HSP90AA1.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175. |
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| Sequence variations |
- Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
- Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Gly464Val (c.1391G>T); ClinVar=VCV000040364; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg280Lys (c.839G>A); ClinVar=VCV000376657; Zygosity=Homozygous (from parent cell line).
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| Disease |
Breast adenocarcinoma (NCIt: C5214) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0062 (MDA-MB-231) |
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| Sex of cell |
Female |
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| Age at sampling |
51Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=27721406; DOI=10.1038/onc.2016.375; PMCID=PMC5386837
Meng-Chen Zou, Ayesha Bhatia, Hang-Ming Dong, Priyamvada Jayaprakash, Jia-Cong Guo, Divya Sahu, Ying-Ping Hou, Fred Tsen, Chang Tong, Kathryn O'Brien, Alan Jia-Lun Situ ...Show all 17 authors... , Thomas Schmidt, Mo-Mei Chen, Qi-Long Ying, Tobias S. Ulmer, David Timothy Woodley, Wei Li; Show fewer authors
Evolutionarily conserved dual lysine motif determines the non-chaperone function of secreted Hsp90alpha in tumour progression.
Oncogene 36:2160-2171(2017) |
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| Entry history |
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| Entry creation | 14-Aug-2025 |
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| Last entry update | 14-Aug-2025 |
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| Version number | 1 |
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