ID   MDA-MB-231 HSP90AA1 KO#2
AC   CVCL_E9EB
SY   KO-alpha-#2; KO-alpha#2
RX   PubMed=27721406;
CC   Group: Triple negative breast cancer (TNBC) cell line.
CC   Population: Caucasian.
CC   Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:5253; HSP90AA1.
CC   Sequence variation: Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Gly464Val (c.1391G>T); ClinVar=VCV000040364; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg280Lys (c.839G>A); ClinVar=VCV000376657; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C5214; Breast adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0062 ! MDA-MB-231
SX   Female
AG   51Y
CA   Cancer cell line
DT   Created: 14-08-25; Last updated: 14-08-25; Version: 1
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RX   PubMed=27721406; DOI=10.1038/onc.2016.375; PMCID=PMC5386837;
RA   Zou, Meng-Chen
RA   Bhatia, Ayesha
RA   Dong, Hang-Ming
RA   Jayaprakash, Priyamvada
RA   Guo, Jia-Cong
RA   Sahu, Divya
RA   Hou, Ying-Ping
RA   Tsen, Fred
RA   Tong, Chang
RA   O'Brien, Kathryn
RA   Situ, Alan Jia-Lun
RA   Schmidt, Thomas
RA   Chen, Mo-Mei
RA   Ying, Qi-Long
RA   Ulmer, Tobias S.
RA   Woodley, David Timothy
RA   Li, Wei
RT   "Evolutionarily conserved dual lysine motif determines the
RT   non-chaperone function of secreted Hsp90alpha in tumour progression.";
RL   Oncogene 36:2160-2171(2017).
//