| Cell line name |
5555 |
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| Accession |
CVCL_E9CJ |
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| Resource Identification Initiative |
To cite this cell line use: 5555 (RRID:CVCL_E9CJ) |
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| Comments |
Genetic integration: Method=Transgenic mouse; Gene=MGI; MGI:1352467; Esr1 (Note=Ligand binding domain; with p.Gly525Arg. Fused to Cre = CreERT2).
Breed/subspecies: C57BL/6 BRAF+/LSL-BRAFV600E;Tyr::CreERT2+/o transgenic. |
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| Sequence variations |
- Mutation; MGI; MGI:88190; Braf; Simple; p.Val637Glu (c.1910T>A); Zygosity=Heterozygous (PubMed=25873177).
|
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| Disease |
Mouse melanoma (NCIt: C21790) |
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| Species of origin |
Mus musculus (Mouse)
(NCBI Taxonomy: 10090) |
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| Hierarchy |
Children:
|
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| Sex of cell |
Sex unspecified |
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| Age at sampling |
Age unspecified |
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| Category |
Cancer cell line |
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| Publications | DOI=10.4161/intv.24790
Cerys S. Manning, Robert P. Jenkins, Steven Hooper, Holger Gerhardt, Richard Marais, Susanne Adams, Ralf Heinrich Adams, Jacco van Rheenen, Erik Sahai;
Intravital imaging reveals conversion between distinct tumor vascular morphologies and localized vascular response to Sunitinib.
IntraVital 2:e24790.1-e24790.13(2013) PubMed=25873177; DOI=10.1016/j.ccell.2015.03.008; PMCID=PMC4402404
Eishu Hirata, Maria Romina Girotti, Amaya Viros, Steven Hooper, Bradley Spencer-Dene, Michiyuki Matsuda, James Larkin, Richard Marais, Erik Sahai;
Intravital imaging reveals how BRAF inhibition generates drug-tolerant microenvironments with high integrin beta1/FAK signaling.
Cancer Cell 27:574-588(2015) PubMed=26414886; DOI=10.1111/pcmr.12424; PMCID=PMC4737278
Heike Seifert, Eishu Hirata, Martin Eric Gore, Komel Khabra, Christina Messiou, James Larkin, Erik Sahai;
Extrinsic factors can mediate resistance to BRAF inhibition in central nervous system melanoma metastases.
Pigment Cell Melanoma Res. 29:92-100(2016) |
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| Entry history |
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| Entry creation | 14-Aug-2025 |
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| Last entry update | 14-Aug-2025 |
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| Version number | 1 |
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