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Cellosaurus WaGa (CVCL_E998)

[Text version]
Cell line name WaGa
Synonyms WAGA
Accession CVCL_E998
Resource Identification Initiative To cite this cell line use: WaGa (RRID:CVCL_E998)
Comments Doubling time: 4 days (PubMed=20444890); 2-3 days (PubMed=30873613).
Transformant: NCBI_TaxID; 493803; Merkel cell polyomavirus (MCPyV).
Omics: Array-based CGH.
Omics: Deep quantitative proteome analysis.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Disease Merkel cell carcinoma (NCIt: C9231)
Cutaneous neuroendocrine carcinoma (ORDO: Orphanet_79140)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 67Y
Category Cancer cell line
STR profile Source(s): PubMed=30873613

Penta D12
Penta E5,10

Run an STR similarity search on this cell line

PubMed=20444890; DOI=10.1128/JVI.02400-09
Houben R., Shuda M., Weinkam R., Schrama D., Feng H.-C., Chang Y., Moore P.S., Becker J.C.
Merkel cell polyomavirus-infected Merkel cell carcinoma cells require expression of viral T antigens.
J. Virol. 84:7064-7072(2010)

PubMed=22363598; DOI=10.1371/journal.pone.0031255
Hafner C., Houben R., Baeurle A., Ritter C., Schrama D., Landthaler M., Becker J.C.
Activation of the PI3K/AKT pathway in Merkel cell carcinoma.
PLoS ONE 7:E31255-E31255(2012)

PubMed=23563200; DOI=10.1038/jid.2013.169
Houben R., Dreher C., Angermeyer S., Borst A., Utikal J.S., Haferkamp S., Peitsch W.K., Schrama D., Hesbacher S.
Mechanisms of p53 restriction in Merkel cell carcinoma cells are independent of the Merkel cell polyoma virus T antigens.
J. Invest. Dermatol. 133:2453-2460(2013)

PubMed=27121059; DOI=10.18632/oncotarget.8793
Hesbacher S., Pfitzer L., Wiedorfer K., Angermeyer S., Borst A., Haferkamp S., Scholz C.-J., Wobser M., Schrama D., Houben R.
RB1 is the crucial target of the Merkel cell polyomavirus Large T antigen in Merkel cell carcinoma cells.
Oncotarget 7:32956-32968(2016)

PubMed=30873613; DOI=10.1002/ijc.32280
Schrama D., Sarosi E.-M., Adam C., Ritter C., Kaemmerer U., Klopocki E., Konig E.-M., Utikal J.S., Becker J.C., Houben R.
Characterization of six Merkel cell polyomavirus-positive Merkel cell carcinoma cell lines: integration pattern suggest that large T antigen truncating events occur before or during integration.
Int. J. Cancer 145:1020-1032(2019)

PubMed=31889939; DOI=10.1186/s12014-019-9263-z
Kotowski U., Erovic B.M., Schnoll J., Stanek V., Janik S., Steurer M., Mitulovic G.
Quantitative proteome analysis of Merkel cell carcinoma cell lines using SILAC.
Clin. Proteomics 16:42.1-42.13(2019)

Encyclopedic resources Wikidata; Q54993575
Polymorphism and mutation databases Cosmic; 1699819
Cosmic; 2273918
Proteomic databases PRIDE; PXD008181
Entry history
Entry creation22-Oct-2012
Last entry update29-Jun-2023
Version number16