ID   WaGa
AC   CVCL_E998
SY   WAGA
DR   Cosmic; 1699819
DR   Cosmic; 2273918
DR   PRIDE; PXD008181
DR   Wikidata; Q54993575
RX   PubMed=20444890;
RX   PubMed=22363598;
RX   PubMed=23563200;
RX   PubMed=27121059;
RX   PubMed=30873613;
RX   PubMed=31889939;
CC   Doubling time: 4 days (PubMed=20444890); 2-3 days (PubMed=30873613).
CC   Transformant: NCBI_TaxID; 493803; Merkel cell polyomavirus (MCPyV).
CC   Omics: Array-based CGH.
CC   Omics: Deep quantitative proteome analysis.
CC   Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
ST   Source(s): PubMed=30873613
ST   Amelogenin: X,Y
ST   CSF1PO: 12
ST   D13S317: 8,13
ST   D16S539: 11,12
ST   D18S51: 10,13
ST   D21S11: 28,30
ST   D3S1358: 14
ST   D5S818: 12
ST   D7S820: 10
ST   D8S1179: 10,13
ST   FGA: 19
ST   Penta D: 12
ST   Penta E: 5,10
ST   TH01: 9.3
ST   TPOX: 8,11
ST   vWA: 16,17
DI   NCIt; C9231; Merkel cell carcinoma
DI   ORDO; Orphanet_79140; Cutaneous neuroendocrine carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   67Y
CA   Cancer cell line
DT   Created: 22-10-12; Last updated: 29-06-23; Version: 16
//
RX   PubMed=20444890; DOI=10.1128/JVI.02400-09;
RA   Houben R., Shuda M., Weinkam R., Schrama D., Feng H.-C., Chang Y.,
RA   Moore P.S., Becker J.C.;
RT   "Merkel cell polyomavirus-infected Merkel cell carcinoma cells require
RT   expression of viral T antigens.";
RL   J. Virol. 84:7064-7072(2010).
//
RX   PubMed=22363598; DOI=10.1371/journal.pone.0031255;
RA   Hafner C., Houben R., Baeurle A., Ritter C., Schrama D.,
RA   Landthaler M., Becker J.C.;
RT   "Activation of the PI3K/AKT pathway in Merkel cell carcinoma.";
RL   PLoS ONE 7:E31255-E31255(2012).
//
RX   PubMed=23563200; DOI=10.1038/jid.2013.169;
RA   Houben R., Dreher C., Angermeyer S., Borst A., Utikal J.S.,
RA   Haferkamp S., Peitsch W.K., Schrama D., Hesbacher S.;
RT   "Mechanisms of p53 restriction in Merkel cell carcinoma cells are
RT   independent of the Merkel cell polyoma virus T antigens.";
RL   J. Invest. Dermatol. 133:2453-2460(2013).
//
RX   PubMed=27121059; DOI=10.18632/oncotarget.8793;
RA   Hesbacher S., Pfitzer L., Wiedorfer K., Angermeyer S., Borst A.,
RA   Haferkamp S., Scholz C.-J., Wobser M., Schrama D., Houben R.;
RT   "RB1 is the crucial target of the Merkel cell polyomavirus Large T
RT   antigen in Merkel cell carcinoma cells.";
RL   Oncotarget 7:32956-32968(2016).
//
RX   PubMed=30873613; DOI=10.1002/ijc.32280;
RA   Schrama D., Sarosi E.-M., Adam C., Ritter C., Kaemmerer U.,
RA   Klopocki E., Konig E.-M., Utikal J.S., Becker J.C., Houben R.;
RT   "Characterization of six Merkel cell polyomavirus-positive Merkel cell
RT   carcinoma cell lines: integration pattern suggest that large T antigen
RT   truncating events occur before or during integration.";
RL   Int. J. Cancer 145:1020-1032(2019).
//
RX   PubMed=31889939; DOI=10.1186/s12014-019-9263-z;
RA   Kotowski U., Erovic B.M., Schnoll J., Stanek V., Janik S., Steurer M.,
RA   Mitulovic G.;
RT   "Quantitative proteome analysis of Merkel cell carcinoma cell lines
RT   using SILAC.";
RL   Clin. Proteomics 16:42.1-42.13(2019).
//