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Cellosaurus MS-1 [Human Merkel cell carcinoma] (CVCL_E995)

[Text version]
Cell line name MS-1 [Human Merkel cell carcinoma]
Accession CVCL_E995
Resource Identification Initiative To cite this cell line use: MS-1 [Human Merkel cell carcinoma] (RRID:CVCL_E995)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Virology: Contains 2.1 copies of the genome of MCPyV per haploid cell (PubMed=23085629).
Doubling time: 4 days (PubMed=20444890); 3 days (PubMed=30873613).
Transformant: NCBI_TaxID; 493803; Merkel cell polyomavirus (MCPyV).
Omics: Array-based CGH.
Omics: Deep exome analysis.
Derived from site: Metastatic; Adrenal gland; UBERON=UBERON_0002369.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.Ile251_Thr253del; Zygosity=Hemizygous (PubMed=23563200).
Disease Merkel cell carcinoma (NCIt: C9231)
Cutaneous neuroendocrine carcinoma (ORDO: Orphanet_79140)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 59Y
Category Cancer cell line
STR profile Source(s): ECACC; PubMed=30873613

Penta D12,14
Penta E8,19

Run an STR similarity search on this cell line

PubMed=20444890; DOI=10.1128/JVI.02400-09
Houben R., Shuda M., Weinkam R., Schrama D., Feng H.-C., Chang Y., Moore P.S., Becker J.C.
Merkel cell polyomavirus-infected Merkel cell carcinoma cells require expression of viral T antigens.
J. Virol. 84:7064-7072(2010)

PubMed=23085629; DOI=10.1016/j.jviromet.2012.10.001
Guastafierro A., Feng H., Thant M., Kirkwood J.M., Chang Y., Moore P.S., Shuda M.
Characterization of an early passage Merkel cell polyomavirus-positive Merkel cell carcinoma cell line, MS-1, and its growth in NOD scid gamma mice.
J. Virol. Methods 187:6-14(2013)

PubMed=23563200; DOI=10.1038/jid.2013.169
Houben R., Dreher C., Angermeyer S., Borst A., Utikal J.S., Haferkamp S., Peitsch W.K., Schrama D., Hesbacher S.
Mechanisms of p53 restriction in Merkel cell carcinoma cells are independent of the Merkel cell polyoma virus T antigens.
J. Invest. Dermatol. 133:2453-2460(2013)

PubMed=29696010; DOI=10.3389/fmicb.2018.00713
Velasquez C., Amako Y., Harold A., Toptan T., Chang Y., Shuda M.
Characterization of a Merkel cell polyomavirus-positive Merkel cell carcinoma cell line CVG-1.
Front. Microbiol. 9:713.1-713.10(2018)

PubMed=30873613; DOI=10.1002/ijc.32280
Schrama D., Sarosi E.-M., Adam C., Ritter C., Kaemmerer U., Klopocki E., Konig E.-M., Utikal J.S., Becker J.C., Houben R.
Characterization of six Merkel cell polyomavirus-positive Merkel cell carcinoma cell lines: integration pattern suggest that large T antigen truncating events occur before or during integration.
Int. J. Cancer 145:1020-1032(2019)

Cell line collections (Providers) ECACC; 09111802
HIVReagentProgram; ARP-11714
Cell line databases/resources cancercelllines; CVCL_E995
Cell_Model_Passport; SIDM00408
DepMap; ACH-001131
Encyclopedic resources Wikidata; Q54906753
Entry history
Entry creation22-Oct-2012
Last entry update05-Oct-2023
Version number21