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Cellosaurus MS-1 [Human Merkel cell carcinoma] (CVCL_E995)

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Cell line name MS-1 [Human Merkel cell carcinoma]
Accession CVCL_E995
Resource Identification Initiative To cite this cell line use: MS-1 [Human Merkel cell carcinoma] (RRID:CVCL_E995)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Virology: Contains 2.1 copies of the genome of MCPyV per haploid cell (PubMed=23085629).
Doubling time: 4 days (PubMed=20444890); 3 days (PubMed=30873613).
Transformant: NCBI_TaxID; 493803; Merkel cell polyomavirus (MCPyV).
Omics: Genomics; Whole exome sequencing.
Omics: Variations; Array-based CGH.
Derived from site: Metastatic; Adrenal gland; UBERON=UBERON_0002369.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ile251_Thr253del; Zygosity=Hemizygous (PubMed=23563200).
Disease Merkel cell carcinoma (NCIt: C9231)
Cutaneous neuroendocrine carcinoma (ORDO: Orphanet_79140)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 59Y
Category Cancer cell line
STR profile Source(s): ECACC=09111802; PubMed=30873613

Markers:
AmelogeninX
CSF1PO10
D3S135814,15.2
D5S81811
D7S8208,9
D8S117910,14
D13S31711,14
D16S5399
D18S5113,14
D21S1132
FGA20,21
Penta D12,14
Penta E8,19
TH017,9.3
TPOX8
vWA17

Run an STR similarity search on this cell line
Publications

PubMed=20444890; DOI=10.1128/JVI.02400-09; PMCID=PMC2898224
Roland Houben, Masahiro Shuda, Rita Weinkam, David Schrama, Hui-Chen Feng, Yuan Chang, Patrick S. Moore, Jurgen C. Becker;
Merkel cell polyomavirus-infected Merkel cell carcinoma cells require expression of viral T antigens.
J. Virol. 84:7064-7072(2010)

PubMed=23085629; DOI=10.1016/j.jviromet.2012.10.001; PMCID=PMC3606892
Anna Guastafierro, Hui-Chen Feng, Mamie Thant, John Munn Kirkwood, Yuan Chang, Patrick S. Moore, Masahiro Shuda;
Characterization of an early passage Merkel cell polyomavirus-positive Merkel cell carcinoma cell line, MS-1, and its growth in NOD scid gamma mice.
J. Virol. Methods 187:6-14(2013)

PubMed=23563200; DOI=10.1038/jid.2013.169
Roland Houben, Christina Dreher, Sabrina Angermeyer, Andreas Borst, Jochen Sven Utikal, Sebastian Haferkamp, Wiebke K. Peitsch, David Schrama, Sonja Hesbacher;
Mechanisms of p53 restriction in Merkel cell carcinoma cells are independent of the Merkel cell polyoma virus T antigens.
J. Invest. Dermatol. 133:2453-2460(2013)

PubMed=29696010; DOI=10.3389/fmicb.2018.00713; PMCID=PMC5905237
Celestino Velasquez, Yutaka Amako, Alexis Harold, Tuna Toptan, Yuan Chang, Masahiro Shuda;
Characterization of a Merkel cell polyomavirus-positive Merkel cell carcinoma cell line CVG-1.
Front. Microbiol. 9:713.1-713.10(2018)

PubMed=30873613; DOI=10.1002/ijc.32280
David Schrama, Eva-Maria Sarosi, Christian Adam, Cathrin Ritter, Ulrike Kaemmerer, Eva Klopocki, Eva-Maria Konig, Jochen Sven Utikal, Jurgen C. Becker, Roland Houben;
Characterization of six Merkel cell polyomavirus-positive Merkel cell carcinoma cell lines: integration pattern suggest that large T antigen truncating events occur before or during integration.
Int. J. Cancer 145:1020-1032(2019)

Cross-references
Cell line collections (Providers) BEI_Resources; ARP-11714
ECACC; 09111802
Cell line databases/resources cancercelllines; CVCL_E995
Cell_Model_Passport; SIDM00408
DepMap; ACH-001131
Encyclopedic resources Wikidata; Q54906753
Gene expression databases FANTOM5_SSTAR; 10844-111E7
Entry history
Entry creation22-Oct-2012
Last entry update10-Apr-2025
Version number25