ID   MS-1 [Human Merkel cell carcinoma]
AC   CVCL_E995
DR   cancercelllines; CVCL_E995
DR   Cell_Model_Passport; SIDM00408
DR   DepMap; ACH-001131
DR   ECACC; 09111802
DR   HIVReagentProgram; ARP-11714
DR   Wikidata; Q54906753
RX   PubMed=20444890;
RX   PubMed=23085629;
RX   PubMed=23563200;
RX   PubMed=29696010;
RX   PubMed=30873613;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Virology: Contains 2.1 copies of the genome of MCPyV per haploid cell (PubMed=23085629).
CC   Doubling time: 4 days (PubMed=20444890); 3 days (PubMed=30873613).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Ile251_Thr253del; Zygosity=Hemizygous (PubMed=23563200).
CC   Transformant: NCBI_TaxID; 493803; Merkel cell polyomavirus (MCPyV).
CC   Omics: Array-based CGH.
CC   Omics: Deep exome analysis.
CC   Derived from site: Metastatic; Adrenal gland; UBERON=UBERON_0002369.
ST   Source(s): ECACC; PubMed=30873613
ST   Amelogenin: X
ST   CSF1PO: 10
ST   D13S317: 11,14
ST   D16S539: 9
ST   D18S51: 13,14
ST   D21S11: 32
ST   D3S1358: 14,15.2
ST   D5S818: 11
ST   D7S820: 8,9
ST   D8S1179: 10,14
ST   FGA: 20,21
ST   Penta D: 12,14
ST   Penta E: 8,19
ST   TH01: 7,9.3
ST   TPOX: 8
ST   vWA: 17
DI   NCIt; C9231; Merkel cell carcinoma
DI   ORDO; Orphanet_79140; Cutaneous neuroendocrine carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   59Y
CA   Cancer cell line
DT   Created: 22-10-12; Last updated: 05-10-23; Version: 21
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RX   PubMed=20444890; DOI=10.1128/JVI.02400-09;
RA   Houben R., Shuda M., Weinkam R., Schrama D., Feng H.-C., Chang Y.,
RA   Moore P.S., Becker J.C.;
RT   "Merkel cell polyomavirus-infected Merkel cell carcinoma cells require
RT   expression of viral T antigens.";
RL   J. Virol. 84:7064-7072(2010).
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RX   PubMed=23085629; DOI=10.1016/j.jviromet.2012.10.001;
RA   Guastafierro A., Feng H.-C., Thant M., Kirkwood J.M., Chang Y.,
RA   Moore P.S., Shuda M.;
RT   "Characterization of an early passage Merkel cell polyomavirus-positive
RT   Merkel cell carcinoma cell line, MS-1, and its growth in NOD scid gamma
RT   mice.";
RL   J. Virol. Methods 187:6-14(2013).
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RX   PubMed=23563200; DOI=10.1038/jid.2013.169;
RA   Houben R., Dreher C., Angermeyer S., Borst A., Utikal J.S.,
RA   Haferkamp S., Peitsch W.K., Schrama D., Hesbacher S.;
RT   "Mechanisms of p53 restriction in Merkel cell carcinoma cells are
RT   independent of the Merkel cell polyoma virus T antigens.";
RL   J. Invest. Dermatol. 133:2453-2460(2013).
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RX   PubMed=29696010; DOI=10.3389/fmicb.2018.00713;
RA   Velasquez C., Amako Y., Harold A., Toptan T., Chang Y., Shuda M.;
RT   "Characterization of a Merkel cell polyomavirus-positive Merkel cell
RT   carcinoma cell line CVG-1.";
RL   Front. Microbiol. 9:713.1-713.10(2018).
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RX   PubMed=30873613; DOI=10.1002/ijc.32280;
RA   Schrama D., Sarosi E.-M., Adam C., Ritter C., Kaemmerer U.,
RA   Klopocki E., Konig E.-M., Utikal J.S., Becker J.C., Houben R.;
RT   "Characterization of six Merkel cell polyomavirus-positive Merkel cell
RT   carcinoma cell lines: integration pattern suggest that large T antigen
RT   truncating events occur before or during integration.";
RL   Int. J. Cancer 145:1020-1032(2019).
//