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Cellosaurus HepG2-CYP3A22 (CVCL_E8Z3)

[Text version]
Cell line name HepG2-CYP3A22
Accession CVCL_E8Z3
Resource Identification Initiative To cite this cell line use: HepG2-CYP3A22 (RRID:CVCL_E8Z3)
Comments Population: Caucasian.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Genetic integration: Method=Transfection; Gene=VGNC; VGNC:103554; Pig CYP3A22.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Hepatoblastoma (NCIt: C3728)
Hepatoblastoma (ORDO: Orphanet_449)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0027 (Hep-G2)
Sex of cell Male
Age at sampling 15Y
Category Cancer cell line
Publications

CLPUB00804
Zheng-Kai Xue, Hong Wei, Hai-Tao Shang, Gen-Qing Yang, Bin Ye;
Establishment of a HepG2 cell line stably expressing CYP3A22 and identification of the metabolic activity of the probe drugs.
Di 3 Jun Yi Da Xue Xue Bao 31:1552-1555(2009)

Entry history
Entry creation14-Aug-2025
Last entry update14-Aug-2025
Version number1