Cellosaurus cell line FaDu ATM KO clone 1B6 (CVCL

Cross-references
Cell line name	FaDu ATM KO clone 1B6
Synonyms	FaDu-ATM-KO-1B6
Accession	CVCL_E8SM
Resource Identification Initiative	To cite this cell line use: FaDu ATM KO clone 1B6 (RRID:CVCL_E8SM)
Comments	Population: Indian. Doubling time: ~50 hours (KYinno=KC-4287). Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:795; ATM. Derived from site: In situ; Pharynx, hypopharynx; UBERON=UBERON_0001051. Cell type: Epithelial cell; CL=CL_0000066.
Sequence variations	Mutation; HGNC; HGNC:1787; CDKN2A; Simple; c.151-1G>T; ClinVar=VCV000422058; Zygosity=Homozygous; Note=Splice acceptor mutation (from parent cell line). Mutation; HGNC; HGNC:3595; FAT1; Simple; p.Lys3277Asnfs*4 (c.9828delG) (p.Gly3276fs); Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:11998; TP53; Simple; c.376-1G>A (p.Tyr126_Lys132del, c.376_396del21); ClinVar=VCV000481003; Zygosity=Heterozygous; Note=Splice acceptor mutation (from parent cell line). Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Leu (c.743G>T); ClinVar=VCV000230253; Zygosity=Heterozygous (from parent cell line).
Disease	Hypopharyngeal squamous cell carcinoma (NCIt: C4043) Squamous cell carcinoma of the hypopharynx (ORDO: Orphanet_494547)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_1218 (FaDu)
Sex of cell	Male
Age at sampling	56Y
Category	Cancer cell line
Cell line collections (Providers)	KYinno; KC-4287
Entry history
Entry creation	14-Aug-2025
Last entry update	14-Aug-2025
Version number	1