Cellosaurus cell line 22Rv1 CHD7 KO clone 2A2 (CVCL

Cross-references
Cell line name	22Rv1 CHD7 KO clone 2A2
Synonyms	22Rv1-CHD7-KO-2A2
Accession	CVCL_E8SC
Resource Identification Initiative	To cite this cell line use: 22Rv1 CHD7 KO clone 2A2 (RRID:CVCL_E8SC)
Comments	Population: Caucasian. Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:20626; CHD7. Derived from site: In situ; Prostate; UBERON=UBERON_0002367.
Sequence variations	Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Leu597Arg (c.1790T>G); ClinVar=VCV000013968; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:7133; KMT2D; Simple; p.Arg1252Ter (c.3754C>T); ClinVar=VCV000167228; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:7133; KMT2D; Simple; p.Gln3158Ter (c.9472C>T); Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Gln546Arg (c.1637A>G); ClinVar=VCV000045466; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln331Arg (c.992A>G); ClinVar=VCV000421319; Zygosity=Heterozygous (from parent cell line).
Disease	Prostate carcinoma (NCIt: C4863)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_1045 (22Rv1)
Sex of cell	Male
Age at sampling	Adult
Category	Cancer cell line
Cell line collections (Providers)	KYinno; KC-4252
Entry history
Entry creation	14-Aug-2025
Last entry update	14-Aug-2025
Version number	1