| Cell line name |
A375 RL |
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| Synonyms |
A375-RL |
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| Accession |
CVCL_E8FX |
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| Resource Identification Initiative |
To cite this cell line use: A375 RL (RRID:CVCL_E8FX) |
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| Comments |
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_63637; Vemurafenib (Zelboraf; PLX4032).
Derived from site: In situ; Leg, skin; UBERON=UBERON_0001511. |
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| Sequence variations |
- Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Glu61Ter (c.181G>T) (p.Gly75Val, c.224G>T); ClinVar=VCV000376309; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Glu69Ter (c.205G>T) (p.Gly83Val, c.248G>T); ClinVar=VCV000376308; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
|
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| Disease |
Amelanotic melanoma (NCIt: C3802) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0132 (A-375) |
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| Sex of cell |
Female |
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| Age at sampling |
54Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=31877948; DOI=10.3390/ijms21010113; PMCID=PMC6981576
Ewelina Dratkiewicz, Aleksandra Simiczyjew, Katarzyna Pietraszek-Gremplewicz, Justyna Wadzynska, Dorota Nowak;
Characterization of melanoma cell lines resistant to vemurafenib and evaluation of their responsiveness to EGFR- and MET-inhibitor treatment.
Int. J. Mol. Sci. 21:113.1-113.20(2019) |
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| Cross-references |
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| Cell line collections (Providers) |
ABM; T3350
|
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| Entry history |
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| Entry creation | 14-Aug-2025 |
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| Last entry update | 14-Aug-2025 |
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| Version number | 1 |
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