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Cellosaurus KS1/4 (CVCL_E7ZR)

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Cell line name KS1/4
Accession CVCL_E7ZR
Resource Identification Initiative To cite this cell line use: KS1/4 (RRID:CVCL_E7ZR)
Comments Biotechnology: The monoclonal antibody produced by this hybridoma was conjugated to to methotrexate (KS1/4-methotrexate) or vinblastine (KS1/4-DAVLB or LY256787) in phase 1 clinical studies in patients with non-small cell lung carcinoma. These studies were stopped because of human anti-murine antibody (HAMA) response.
Monoclonal antibody isotype: IgG2a, kappa.
Monoclonal antibody target: UniProtKB; P16422; Human EPCAM/CD326.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Hierarchy Parent: CVCL_3411 (P3X63Ag8)
Category Hybridoma
Publications

PubMed=6362852
Nissi Mary Varki, Ralph Alfred Reisfeld, Leslie E. Walker;
Antigens associated with a human lung adenocarcinoma defined by monoclonal antibodies.
Cancer Res. 44:681-687(1984)

PubMed=2469722; DOI=10.4049/jimmunol.142.10.3662
Mary S. Perez, Leslie E. Walker;
Isolation and characterization of a cDNA encoding the KS1/4 epithelial carcinoma marker.
J. Immunol. 142:3662-3667(1989)

Cross-references
Biological sample resources ABCD; ABCD_BE890
Entry history
Entry creation10-Apr-2025
Last entry update10-Apr-2025
Version number1