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Cellosaurus HEK-293 rCTR C1a clone F12 (CVCL_E7XD)

[Text version]
Cell line name HEK-293 rCTR C1a clone F12
Synonyms F12
Accession CVCL_E7XD
Resource Identification Initiative To cite this cell line use: HEK-293 rCTR C1a clone F12 (RRID:CVCL_E7XD)
Comments Characteristics: Expresses ~60,000 receptors/cell (PubMed=7723741).
Genetic integration: Method=Transfection; Gene=RGD; 621001; Calcr (Note=Isoform C1a).
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Transformant: NCBI_TaxID; 28285; Adenovirus 5.
Derived from site: In situ; Fetal kidney; UBERON=UBERON_0002113.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0045 (HEK293)
Sex of cell Female
Age at sampling Fetus
Category Transformed cell line
Publications

PubMed=7723741; DOI=10.1016/S0026-895X(25)08628-6
Houssami S., Findlay D.M., Brady C.L., Martin T.J., Epand R.M., Moore E.E., Murayama E., Tamura T., Orlowski R.C., Sexton P.M.
Divergent structural requirements exist for calcitonin receptor binding specificity and adenylate cyclase activation.
Mol. Pharmacol. 47:798-809(1995)

PubMed=10517675; DOI=10.1210/mend.13.10.0359
Evdokiou A., Raggatt L.-J., Atkins G.J., Findlay D.M.
Calcitonin receptor-mediated growth suppression of HEK-293 cells is accompanied by induction of p21WAF1/CIP1 and G2/M arrest.
Mol. Endocrinol. 13:1738-1750(1999)

Entry history
Entry creation10-Apr-2025
Last entry update10-Apr-2025
Version number1