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Cellosaurus HEK-293 rCTR C1a clone F12 (CVCL_E7XD)

[Text version]
Cell line name HEK-293 rCTR C1a clone F12
Synonyms F12
Accession CVCL_E7XD
Resource Identification Initiative To cite this cell line use: HEK-293 rCTR C1a clone F12 (RRID:CVCL_E7XD)
Comments Characteristics: Expresses ~60,000 receptors/cell (PubMed=7723741).
Genetic integration: Method=Transfection; Gene=RGD; 621001; Calcr (Note=Isoform C1a).
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Transformant: NCBI_TaxID; 28285; Human adenovirus C serotype 5.
Derived from site: In situ; Fetal kidney; UBERON=UBERON_0002113.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0045 (HEK293)
Sex of cell Female
Age at sampling Fetus
Category Transformed cell line
Publications

PubMed=7723741; DOI=10.1016/S0026-895X(25)08628-6
Souheir Houssami, David M. Findlay, Catherine L. Brady, Thomas John Martin, Richard M. Epand, Emma E. Moore, Eigoro Murayama, Tatsuya Tamura, Ronald C. Orlowski, Patrick M. Sexton;
Divergent structural requirements exist for calcitonin receptor binding specificity and adenylate cyclase activation.
Mol. Pharmacol. 47:798-809(1995)

PubMed=10517675; DOI=10.1210/mend.13.10.0359
Andreas Evdokiou, Liza-Jane Raggatt, Gerald J. Atkins, David M. Findlay;
Calcitonin receptor-mediated growth suppression of HEK-293 cells is accompanied by induction of p21WAF1/CIP1 and G2/M arrest.
Mol. Endocrinol. 13:1738-1750(1999)

Entry history
Entry creation10-Apr-2025
Last entry update14-Aug-2025
Version number2