Cellosaurus logo
expasy logo

Cellosaurus H1299/LKB1shRNA (CVCL_E7UV)

[Text][XML][JSON]
Cell line name H1299/LKB1shRNA
Accession CVCL_E7UV
Resource Identification Initiative To cite this cell line use: H1299/LKB1shRNA (RRID:CVCL_E7UV)
Comments Population: Caucasian.
Karyotypic information: Has lost chromosome Y (from parent cell line).
Knockout cell: Method=shRNA knockdown; HGNC; HGNC:11389; STK11.
Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR).
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Sequence variations
  • Gene deletion; HGNC; HGNC:11998; TP53; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).
Disease Lung large cell carcinoma (NCIt: C4450)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0060 (NCI-H1299)
Sex of cell Male
Age at sampling 43Y
Category Cancer cell line
Web pages Provider; Emory OTT; 11191; https://emoryott.technologypublisher.com/techcase/11191
Publications

PubMed=18794113; DOI=10.1158/0008-5472.CAN-08-1484; PMCID=PMC2596073
Dian-Sheng Zhong, Xiu-Ju Liu, Fadlo R. Khuri, Shi-Yong Sun, Paula M. Vertino, Wei Zhou;
LKB1 is necessary for Akt-mediated phosphorylation of proapoptotic proteins.
Cancer Res. 68:7270-7277(2008)

Entry history
Entry creation10-Apr-2025
Last entry update14-Aug-2025
Version number2