Cellosaurus cell line KK-Luc (CVCL

Cellosaurus KK-Luc (CVCL_E7RV)

[Text version]

Cell line name

KK-Luc

Accession

CVCL_E7RV

Resource Identification Initiative

To cite this cell line use: KK-Luc (RRID:CVCL_E7RV)

Comments

Population: Caucasian.
Characteristics: The luciferase reporter gene is under the control of 5 tandem copies of the NF-kappaB response element (PubMed=21910993).
Genetic integration: Method=Transfection; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Genetic integration: Method=Transfection; Gene=UniProtKB; P08659; Firefly luciferase.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.

Sequence variations

Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (from parent cell line).
Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln136fs*13 (c.406_407insC); Zygosity=Homozygous (from parent cell line).

Disease

Blast phase chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C9110)
Chronic myeloid leukemia (ORDO: Orphanet_521)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy

Parent: CVCL_0004 (K-562)
Children:

CVCL_E7RU (iLite TNF-alpha Assay Ready Cells)

Sex of cell

Female

Age at sampling

53Y