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Cellosaurus U2OS mEGFP-LplA (CVCL_E7RP)

[Text version]
Cell line name U2OS mEGFP-LplA
Accession CVCL_E7RP
Resource Identification Initiative To cite this cell line use: U2OS mEGFP-LplA (RRID:CVCL_E7RP)
Comments Population: Caucasian.
Characteristics: Transduced with a pCDH-mEGFP-LplA construct (PubMed=40069234).
Genetic integration: Method=Transduction; Gene=FPbase; QKFJN; mEGFP (Note=Enhanced GFP).
Genetic integration: Method=Transduction; Gene=UniProtKB; P32099; Escherichia coli lipoate-protein ligase A (lplA).
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Derived from site: In situ; Bone, tibia; UBERON=UBERON_0000979.
Sequence variations
  • Mutation; HGNC; HGNC:9277; PPM1D; Simple; p.Arg458Ter (c.1372C>T); ClinVar=VCV002445214; Zygosity=Heterozygous (from parent cell line).
Disease Osteosarcoma (NCIt: C9145)
Osteosarcoma (ORDO: Orphanet_668)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0042 (U2OS)
Sex of cell Female
Age at sampling 15Y
Category Cancer cell line
Publications

PubMed=40069234; DOI=10.1038/s41467-025-57886-4
Nie J.-L., Zhang X.-Y., Hu Z.-J., Wang W., Schroer M.A., Ren J., Svergun D.I., Chen A.-Y., Yang P.-G., Zeng A.-P.
A globular protein exhibits rare phase behavior and forms chemically regulated orthogonal condensates in cells.
Nat. Commun. 16:2449-2449(2025)

Entry history
Entry creation10-Apr-2025
Last entry update10-Apr-2025
Version number1