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Cellosaurus Ephb266 (CVCL_E7G1)

[Text version]
Cell line name Ephb266
Accession CVCL_E7G1
Resource Identification Initiative To cite this cell line use: Ephb266 (RRID:CVCL_E7G1)
Comments Characteristics: Transduced with an EphB2-IRES-RFP construct. Transduced cells were implanted into the cerebral cortex of CD-1 nu/nu mice and the cell line was established from a tumor (PubMed=20639864).
Knockout cell: Method=KO mouse; MGI; MGI:104738; Cdkn2a.
Genetic integration: Method=Transduction; Gene=FPbase; TXLFX; DsRed2 (Note=Bright red fluorescent protein derived from drFP583 (DsRed)).
Genetic integration: Method=Transduction; Gene=MGI; MGI:99611; Ephb2.
Genetic integration: Method=Transgenic mouse; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
Derived from site: In situ; Embryonic brain, forebrain; UBERON=UBERON_0006240.
Cell type: Neural stem cell; CL=CL_0000047.
Disease Mouse ependymoma (NCIt: C21951)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: Ink4a/Arf-null Blbp-eGFP transgenic.
Sex of cell Sex unspecified
Age at sampling 14-15FD
Category Cancer cell line
Publications

PubMed=20639864; DOI=10.1038/nature09173; PMCID=PMC2912966
Robert A. Johnson, Karen D. Wright, Helen Poppleton, Kumarasamypet Murugesan Mohankumar, David B. Finkelstein, Stanley B. Pounds, Vikki Rand, Sarah E.S. Leary, Elsie L. White, Christopher Eden, Twala L. Hogg ...Show all 29 authors... , Paul A. Northcott, Stephen C. Mack, Geoffrey Neale, Yong-Dong Wang, Beth Coyle, Jennifer Atkinson, Mariko D. DeWire, Tanya A. Kranenburg, George Yancey Gillespie, Jeffrey C. Allen, Thomas E. Merchant, Frederick A. Boop, Robert A. Sanford, Amar Gajjar, David W. Ellison, Michael D. Taylor, Richard G. Grundy, Richard James Gilbertson; Show fewer authors
Cross-species genomics matches driver mutations and cell compartments to model ependymoma.
Nature 466:632-636(2010)

Entry history
Entry creation10-Apr-2025
Last entry update10-Apr-2025
Version number1