Cell line name |
RKO.mp53.13 |
Synonyms |
MP53.13 |
Accession |
CVCL_E7EZ |
Resource Identification Initiative |
To cite this cell line use: RKO.mp53.13 (RRID:CVCL_E7EZ) |
Comments |
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:11998; TP53 (Note=With p.Val143Ala). Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Transposon Tn5 neo. Derived from site: In situ; Colon; UBERON=UBERON_0001155. |
Sequence variations |
- Mutation; HGNC; HGNC:173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11773; TGFBR2; Simple; p.Leu452Pro (c.1355T>C); ClinVar=VCV000930524; Zygosity=Heterozygous (from parent cell line).
|
Disease |
Colon carcinoma (NCIt: C4910) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_E7EX (RKO.mp53) |
Sex of cell |
Sex unspecified |
Age at sampling |
Age unspecified |
Category |
Cancer cell line |
Publications | PubMed=1323840; DOI=10.1073/pnas.89.16.7491; PMCID=PMC49736 Kuerbitz S.J., Plunkett B.S., Walsh W.V., Kastan M.B. Wild-type p53 is a cell cycle checkpoint determinant following irradiation. Proc. Natl. Acad. Sci. U.S.A. 89:7491-7495(1992) PubMed=15161374; DOI=10.1667/rr3160 Franken N.A.P., van Bree C., Haveman J. Differential response to radiation of TP53-inactivated cells by overexpression of dominant-negative mutant TP53 or HPVE6. Radiat. Res. 161:504-510(2004) |
Entry history |
Entry creation | 10-Apr-2025 |
Last entry update | 10-Apr-2025 |
Version number | 1 |
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