| Cell line name |
RKO.mp53 |
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| Accession |
CVCL_E7EX |
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| Resource Identification Initiative |
To cite this cell line use: RKO.mp53 (RRID:CVCL_E7EX) |
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| Comments |
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:11998; TP53 (Note=With p.Val143Ala).
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: In situ; Colon; UBERON=UBERON_0001155. |
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| Sequence variations |
- Mutation; HGNC; HGNC:173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11773; TGFBR2; Simple; p.Leu452Pro (c.1355T>C); ClinVar=VCV000930524; Zygosity=Heterozygous (from parent cell line).
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| Disease |
Colon carcinoma (NCIt: C4910) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0504 (RKO)
Children:
|
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| Sex of cell |
Sex unspecified |
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| Age at sampling |
Age unspecified |
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| Category |
Cancer cell line |
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| Publications | PubMed=1323840; DOI=10.1073/pnas.89.16.7491; PMCID=PMC49736
Steven James Kuerbitz, Beverly S. Plunkett, William V. Walsh, Michael Barry Kastan;
Wild-type p53 is a cell cycle checkpoint determinant following irradiation.
Proc. Natl. Acad. Sci. U.S.A. 89:7491-7495(1992) |
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| Entry history |
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| Entry creation | 10-Apr-2025 |
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| Last entry update | 14-Aug-2025 |
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| Version number | 2 |
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