Cellosaurus cell line MCF-7/CMV (CVCL

Cellosaurus MCF-7/CMV (CVCL_E7E7)

Entry history
Cell line name	MCF-7/CMV
Synonyms	MCF-7/CMV-1
Accession	CVCL_E7E7
Resource Identification Initiative	To cite this cell line use: MCF-7/CMV (RRID:CVCL_E7E7)
Comments	Population: Caucasian. Characteristics: Control cell line for MCF-7/E6 (Cellosaurus=CVCL_M439) and MCF-7/mu-p53 (Cellosaurus=CVCL_E3DM) (PubMed=7712469; PubMed=9563901). Doubling time: 25 hours (PubMed=9563901). Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo. Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations	Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line). Mutation; HGNC; HGNC:4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease	Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_0031 (MCF-7)
Sex of cell	Female
Age at sampling	69Y
Category	Cancer cell line
Publications	PubMed=7712469 Sai-Jun Fan, Martin L. Smith, Dennis J. Rivet 2nd, Diane E. Duba, Qi-Min Zhan, Kurt W. Kohn, Albert J. Fornace Jr., Patrick M. O'Connor; Disruption of p53 function sensitizes breast cancer MCF-7 cells to cisplatin and pentoxifylline. Cancer Res. 55:1649-1654(1995) PubMed=9563901 Sai-Jun Fan, Barry W. Cherney, William C. Reinhold, Kimberly Rucker, Patrick M. O'Connor; Disruption of p53 function in immortalized human cells does not affect survival or apoptosis after taxol or vincristine treatment. Clin. Cancer Res. 4:1047-1054(1998)
Entry creation	10-Apr-2025
Last entry update	14-Aug-2025
Version number	2