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Cellosaurus MCF-7/mu-p53 (CVCL_E3DM)

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Cell line name MCF-7/mu-p53
Synonyms MCF-7/Mu-p53-5
Accession CVCL_E3DM
Resource Identification Initiative To cite this cell line use: MCF-7/mu-p53 (RRID:CVCL_E3DM)
Comments Population: Caucasian.
Doubling time: 22 hours (PubMed=9563901).
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:11998; TP53 (Note=With p.Ala143Val).
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Publications

PubMed=7712469
Sai-Jun Fan, Martin L. Smith, Dennis J. Rivet 2nd, Diane E. Duba, Qi-Min Zhan, Kurt W. Kohn, Albert J. Fornace Jr., Patrick M. O'Connor;
Disruption of p53 function sensitizes breast cancer MCF-7 cells to cisplatin and pentoxifylline.
Cancer Res. 55:1649-1654(1995)

PubMed=9563901
Sai-Jun Fan, Barry W. Cherney, William C. Reinhold, Kimberly Rucker, Patrick M. O'Connor;
Disruption of p53 function in immortalized human cells does not affect survival or apoptosis after taxol or vincristine treatment.
Clin. Cancer Res. 4:1047-1054(1998)

Entry history
Entry creation10-Sep-2024
Last entry update14-Aug-2025
Version number4