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Cellosaurus LIM1215 IR (CVCL_E7AP)

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Cell line name LIM1215 IR
Synonyms LIM 1215 IR
Accession CVCL_E7AP
Resource Identification Initiative To cite this cell line use: LIM1215 IR (RRID:CVCL_E7AP)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_80630; Irinotecan (Camptothecin-11; CPT-11).
Derived from site: Metastatic; Omentum; UBERON=UBERON_0003688.
Sequence variations
  • Mutation; HGNC; HGNC:173; ACVR2A; Simple; p.Pro423Gln (c.1268C>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Thr41Ala (c.121A>G); ClinVar=VCV000017580; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Homozygous (from parent cell line).
Disease Colon adenocarcinoma (NCIt: C4349)
Lynch syndrome (NCIt: C8494)
Lynch syndrome (ORDO: Orphanet_144)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2574 (LIM1215)
Sex of cell Male
Age at sampling 34Y
Category Cancer cell line
Publications

CLPUB00787
Tugce Dilber;
Establishment of irinotecan resistant LIM 1215 cell line and identification of gene expression changes for irinotecan resistance as well as discovering potential second line drugs reverting irinotecan resistance.
Thesis MSc (2024); Middle East Technical University; Ankara; Turkey

Entry history
Entry creation10-Apr-2025
Last entry update10-Apr-2025
Version number1