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Cellosaurus UM-SCC-12-Luc-YFP (CVCL_E6YS)

[Text version]
Cell line name UM-SCC-12-Luc-YFP
Synonyms UMSCC12Luc
Accession CVCL_E6YS
Resource Identification Initiative To cite this cell line use: UM-SCC-12-Luc-YFP (RRID:CVCL_E6YS)
Comments Characteristics: Transfected with a luciferase-YFP fusion protein whose expression is under the control of a CMV promoter (PubMed=22265717).
Genetic integration: Method=Transfection; Gene=FPbase; 8DNLG; YFP (Note=EYFP, yellow fluorescent protein derived from GFP).
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Genetic integration: Method=Transfection; Gene=UniProtKB; P08659; Photinus pyralis firefly-type luciferase.
Derived from site: In situ; Larynx; UBERON=UBERON_0001737.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln104Ter (c.310C>T); ClinVar=VCV000566924; Zygosity=Unspecified (from parent cell line).
Disease Laryngeal squamous cell carcinoma (NCIt: C4044)
Squamous cell carcinoma of the larynx (ORDO: Orphanet_494550)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_7717 (UM-SCC-12)
Sex of cell Male
Age at sampling 71Y
Category Cancer cell line
Publications

PubMed=22265717; DOI=10.1016/j.oraloncology.2011.12.012; PMCID=PMC3350825
Chelsea K. Martin, Wessel P. Dirksen, Sherry T. Shu, Jillian L. Werbeck, Nanda K. Thudi, Mamoru Yamaguchi, Tobie Dianne Wolfe, Kristin N. Heller, Thomas John Rosol;
Characterization of bone resorption in novel in vitro and in vivo models of oral squamous cell carcinoma.
Oral Oncol. 48:491-499(2012)

Entry history
Entry creation10-Apr-2025
Last entry update14-Aug-2025
Version number2