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Cellosaurus Ba/F3 FLT3-ITD-Y842F (CVCL_E6YD)

[Text version]
Cell line name Ba/F3 FLT3-ITD-Y842F
Accession CVCL_E6YD
Resource Identification Initiative To cite this cell line use: Ba/F3 FLT3-ITD-Y842F (RRID:CVCL_E6YD)
Comments Genetic integration: Method=Transduction; Gene=HGNC; HGNC:3765; FLT3 (Note=With ITD and p.Tyr842Phe).
Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
Caution: The parent cell line was originally thought to originate from a BALB/c mouse but is in fact from a C3H mouse.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Cell type: Pro-B cell; CL=CL_0000826.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: C3H.
Hierarchy Parent: CVCL_0161 (Ba/F3)
Category Factor-dependent cell line
Publications

PubMed=28271164; DOI=10.1007/s00018-017-2494-0; PMCID=PMC5487891
Kazi J.U., Chougule R.A., Li T.-F., Su X.-W., Moharram S.A., Rupar K., Marhall A., Gazi M., Sun J.-M., Zhao H., Ronnstrand L.
Tyrosine 842 in the activation loop is required for full transformation by the oncogenic mutant FLT3-ITD.
Cell. Mol. Life Sci. 74:2679-2688(2017)

PubMed=38001685; DOI=10.3390/cancers15225426; PMCID=PMC10670458
Kazi J.U., Al Ashiri L., Purohit R., Ronnstrand L.
Understanding the role of activation loop mutants in drug efficacy for FLT3-ITD.
Cancers (Basel) 15:5426.1-5426.14(2023)

Cross-references
Cell line collections (Providers) ABM; T3682
Entry history
Entry creation10-Apr-2025
Last entry update10-Apr-2025
Version number1